|Eliopoulos team received a competitive JS Latsis Public Benefit Foundation grant
A research proposal by the Eliopoulos team entitled
“Epigenetic regulation of intestinal stem cells in Drosophila melanogaster” was selected for funding by the John S.
Latsis Public Benefit Foundation.
Chronic inflammatory disorders are often associated
with an increased risk of developing cancer. A classic example of the
connection between inflammation and cancer is the increased risk of colorectal
cancer in patients with inflammatory bowel disease. There is considerable
evidence that genetic and environmental factors act through epigenetic
mechanisms in the development of chronic inflammation, altering the expression
of genes involved in signalling pathways, which leads to the transformation of
normal stem cells into cancer cells. By
using Drosophila melanogaster as an in vivo experimental model,
the Eliopoulos team worked to identify the tissue-specific contribution of
epigenetic changes in induced intestinal damage and the regenerative capacity
of intestinal stem cells, aiming to provide novel insights into the complex
interplay between environmental stress, genetics, epigenetics, inflammation and
cancer. This proposal was funded with 12,000 euro for 1 year (2015).