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Publications (Eliopoulos Aristedes)





2016

Orsolic I, Jurada D, Pullen N, Oren M, Eliopoulos AG and Volarevic S: The relationship between the nucleolus and cancer: current evidence and emerging paradigms. Sem. Cancer Biol. (in press).
 

2015

Doxaki C, Kampranis SC, Eliopoulos AG, Spilianakis C, Tsatsanis C: Coordinated Regulation of miR-155 and miR-146a Genes during Induction of Endotoxin Tolerance in Macrophages. J Immunol. 2015 Nov 4. pii: 1500615. [Epub ahead of print] PubMed PMID: 26538391.
Gkouskou KK, Ioannou M, Pavlopoulos GA, Georgila K, Siganou A, Nikolaidis G, Kanellis DC, Moore S, Papadakis KA, Kardassis D, Iliopoulos I, McDyer FA, Drakos E, Eliopoulos AG. Apolipoprotein A-I inhibits experimental colitis and colitis-propelled carcinogenesis. Oncogene. 2015 (in press)
Apidianakis Y, Eliopoulos AG. A holo'ome approach in colon cancer: we change as we age. EMBO Rep. 2015 Oct;16(10):1239-40.
Kanellis DC, Bursac S, Tsichlis PN, Volarevic S, Eliopoulos AG. Physical and functional interaction of the TPL2 kinase with nucleophosmin. Oncogene. 2015 May 7;34(19):2516-26.
Vlahava VM, Eliopoulos AG, Sourvinos G. CD40 ligand exhibits a direct antiviral effect on Herpes Simplex Virus type-1 infection via a PI3K-dependent, autophagy-independent mechanism. Cell Signal. 2015 Jun;27(6):1253-63.
 

2014

Papanikolaou N, Pavlopoulos GA, Pafilis E, Theodosiou T, Schneider R, Satagopam VP, Ouzounis CA, Eliopoulos AG, Promponas VJ, Iliopoulos I. BioTextQuest(+): a knowledge integration platform for literature mining and concept discovery. Bioinformatics. 2014 Nov 15;30(22):3249-56.
Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N, Bracci L, Breckpot K, Brough D, Buque A, Castro MG, Cirone M, Colombo MI, Cremer I, Demaria S, Dini L, Eliopoulos AG, et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology. 2014 Dec 13;3(9):e955691.
Gkouskou KK, Deligianni C, Tsatsanis C, Eliopoulos AG. The gut microbiota in mouse models of inflammatory bowel disease. Front Cell Infect Microbiol. 2014; 4:28.
Liljenfeldt L, Gkirtzimanaki K, Vyrla D, Svensson E, Loskog AS, Eliopoulos AG. Enhanced therapeutic anti-tumor immunity induced by co-administration of 5-fluorouracil and adenovirus expressing CD40 ligand. Cancer Immunol Immunother. 2014;63(3): 273-82.
Leventaki V, Drakos E, Karanikou M, Psatha K, Lin P, Schlette E, Eliopoulos A, Vassilakopoulos TP, Papadaki H, Patsouris E, Medeiros LJ, Rassidakis GZ. c-JUN N-terminal kinase (JNK) is activated and contributes to tumor cell proliferation in classical Hodgkin lymphoma. Hum Pathol. 2014; 45(3):565-72.
 

2013

Miliara S, Gkouskou KK, Sharp TV, Eliopoulos AG. SUMOylation Is Required for Optimal TRAF3 Signaling Capacity. PLoS One. 2013 Nov 18;8(11):e80470.
Gkirtzimanaki K, Gkouskou KK, Oleksiewicz U, Nikolaidis G, Vyrla D, Liontos M, Pelekanou V, Kanellis DC, Evangelou K, Stathopoulos EN, Field JK, Tsichlis PN, Gorgoulis V, Liloglou T, Eliopoulos AG.
TPL2 kinase is a suppressor of lung carcinogenesis. Proc Natl Acad Sci USA. 2013 Apr 16;110(16):E1470-9.
 

2012

Moschonas A, Ioannou M, Eliopoulos AG. CD40 stimulates a "feed-forward" NF-κB-driven molecular pathway that regulates IFN-β expression in carcinoma cells. J Immunol. 2012 Jun 1;188(11):5521-7.
Serebrennikova OB, Tsatsanis C, Mao C, Gounaris E, Ren W, Siracusa LD, Eliopoulos AG, Khazaie K, Tsichlis PN. Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. Proc Natl Acad Sci USA 2012 May 1;109(18):E1082-91.
Diaconu I, Cerullo V, Hirvinen ML, Escutenaire S, Ugolini M, Pesonen SK, Bramante S, Parviainen S, Kanerva A, Loskog AS, Eliopoulos AG, Pesonen S, Hemminki A. Immune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirus. Cancer Res. 2012 May 1;72(9):2327-38.
 

2011

Sideridou M, Zakopoulou R, Evangelou K, Liontos M, Kotsinas A, Rampakakis E, Gagos S, Kahata K, Grabusic K, Gkouskou K, Trougakos IP, Kolettas E, Georgakilas AG, Volarevic S, Eliopoulos AG, Zannis-Hadjopoulos M, Moustakas A, Gorgoulis VG. Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. J Cell Biol. 2011; 195(7):1123-40.
Mavroudi I, Papadaki V, Pyrovolaki K, Katonis P, Eliopoulos AG, Papadaki HA. The CD40/CD40 ligand interactions exert pleiotropic effects on bone marrow granulopoiesis. J Leukoc Biol. 2011; 89:771-83.
Vougioukalaki M, Kanellis DC, Gkouskou K, Eliopoulos AG. Tpl2 kinase signal transduction in inflammation and cancer. Cancer Lett. 2011; 304:80-9.
Knox PG, Davies CC, Ioannou M and Eliopoulos AG: The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas. J. Cell Biol. 2011, 192: 391-399.
Filippakis H, Dimitropoulou P, Eliopoulos AG, Spandidos DA, Sourvinos G. The enhanced host-cell permissiveness of human cytomegalovirus is mediated by the Ras signaling pathway. Biochim Biophys Acta. 2011; 1813(10):1872-82.
 


2010

Mitchell K, Svenson KB, Longmate WM, Gkirtzimanaki K, Sadej R, Wang X, Zhao J, Eliopoulos AG, Berditchevski F, Dipersio CM. Suppression of integrin alpha3beta1 in breast cancer cells reduces cyclooxygenase-2 gene expression and inhibits tumorigenesis, invasion, and cross-talk to endothelial cells. Cancer Res. 2010 Aug 1;70(15):6359-67. PubMed PMID: 20631072.
Watford WT, Wang CC, Tsatsanis C, Mielke LA, Eliopoulos AG, Daskalakis C, Charles N, Odom S, Rivera J, O'Shea J, Tsichlis PN: Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice. J Immunol. 2010 Jan 1;184(1):105-13. PubMed PMID: 19955521.
 


2009

Vardouli L, Lindqvist C, Vlahou K, Loskog AS, Eliopoulos AG. Adenovirus delivery of human CD40 ligand gene confers direct therapeutic effects on carcinomas. Cancer Gene Ther. 2009 Nov;16(11):848-60. PubMed PMID: 19461675.
Loskog AS, Eliopoulos AG: The Janus faces of CD40 in cancer. Semin Immunol. 2009 Oct;21(5):301-7. PubMed PMID: 19647448.
Sadej R, Romanska H, Baldwin G, Gkirtzimanaki K, Novitskaya V, Filer AD, Krcova Z, Kusinska R, Ehrmann J, Buckley CD, Kordek R, Potemski P, Eliopoulos AG, Lalani el-N, Berditchevski F: CD151 regulates tumorigenesis by modulating the communication between tumor cells and endothelium. Mol Cancer Res. 2009 Jun;7(6):787-98. PubMed PMID: 19531562.
Oakley F, Teoh V, Ching-A-Sue G, Bataller R, Colmenero J, Jonsson JR, Eliopoulos AG, Watson MR, Manas D, Mann DA. Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology. 2009 Jun;136(7):2334-2344.e1. PubMed PMID: 19303015.
Pyrovolaki K, Mavroudi I, Sidiropoulos P, Eliopoulos AG, Boumpas DT, Papadaki HA: Increased expression of CD40 on bone marrow CD34+ hematopoietic progenitor cells in patients with systemic lupus erythematosus: Contribution to Fas-mediated apoptosis. Arthritis Rheum. 2009, 60: 543-52.


2008

Moschonas A, Kouraki M, Knox PG, Thymiakou E, Kardassis D & Eliopoulos AG: CD40 Induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. Mol. Cell. Biol. 2008, 28: 6208-6222.
Loskog A and Eliopoulos AG: CD40 Ligand-based Cancer Therapy. In: New Gene Therapy & Cancer Research, 2008, pp 1-7. Ed. WB Gustaffsson, Nova Publishing Group.
Eliopoulos AG: "Make and Brake" in Cell Signaling. Science 2008, 321: 648-649.


2007

Stewart R, Wei W, Challa A, Armitage RJ, Arrand JR, Rowe M, Young LS, Eliopoulos AG, and Gordon J:  CD154 tone sets the signaling pathways and transcriptome generated in model CD40-pluricompetent L3055 Burkitt's lymphoma cells.  J. Immunol. 2007; 179: 2705-2712.


2006

Eliopoulos AG, Das S, Tsichlis PN. The tyrosine kinase SYK regulates TPL2 activation signals.
J Biol Chem. 2006; 281: 1371-1380.


2005

Davies CC, Mak TW, Young LS, Eliopoulos AG: TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells.Mol Cell Biol. 2005; 25:9806-19.
Baxendale AJ, Dawson CW, Stewart SE, Mudaliar V, Reynolds G, Gordon J, Murray PG, Young LS, Eliopoulos AG: Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth. Oncogene 2005 24:7913-7923.
Das S, Cho J, Lambertz I, Kelliher MA, Eliopoulos AG, Du K, Tsichlis PN: Tpl2/Cot signals activate ERK, JNK and NF-kappa B in a cell type and stimulus-specific manner. J Biol Chem. 2005; 280:23748-57.
Papadaki HA, Stamatopoulos K, Damianaki A, Gemetzi C, Anagnostopoulos A, Papadaki T, Eliopoulos AG, Eliopoulos GD: Activated T-lymphocytes with myelosuppressive properties in patients with chronic idiopathic neutropenia. Br J Haematol. 2005; 128:863-76.
Cerimele F, Battle T, Lynch R, Frank DA, Murad E, Cohen C, Macaron N, Sixbey J, Smith K, Watnick RS, Eliopoulos A, Shehata B, Arbiser JL: Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma. Proc. Natl. Acad. Sci. U S A. 2005; 102:175-179.
Hill SC, Youde SJ, Man S, Teale GR, Baxendale AJ, Hislop A, Davies CC, Luesley DM, Blom AM, Rickinson AB, Young LS and Eliopoulos AG: Activation of CD40 in cervical carcinoma cells facilitates cytotoxic T lymphocyte responses and augments chemotherapy-induced apoptosis. J. Immunol. 2005; 174: 41-50.
Davies CC, Bem D, Young LS and Eliopoulos AG: NF-?B overrides the apoptotic program of TNF receptor 1 but not CD40 in carcinoma cells. Cell. Signal. 2005; 17: 729-738.


2004

Eliopoulos AG and Young LS: The role of CD40 in the pathogenesis and treatment of cancer. Curr. Opinion Pharmacol. 2004; 4: 360-367.
Carragher D, Johal R, Button A, White A, Eliopoulos AG, Jenkinson E, Anderson G, Caamano JH: A stroma-derived defect in NF-?B2-/- mice causes impaired lymph node development and lymphocyte recruitment. J Immunol 2004; 173: 2271-2279.
Li HM, Zhuang Z, Wang Q, Wang X, Wong HL, Feng H, Jin D, Ling MT, Wong YC, Eliopoulos AG, Young LS, Huang D, Tsao SW: Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) up-regulates Id1 expression in nasopharyngeal epithelial cells. Oncogene 2004; 23: 4488-4494.
Davies C, Mason J., Wakelam MJO, Young LS, Eliopoulos AG: Inhibition of PI3K and ERK MAPK-regulated protein synthesis unveils the pro-apoptotic properties of CD40 ligation in carcinoma cells. J Biol Chem 2004; 279: 1110-1019.


2003

Eliopoulos AG, Caamano JH, Flavell J, Reynolds GM, Murray PG, Poyet J-L, Young LS: The Epstein-Barr virus-encoded latent infection membrane protein 1 (LMP1) regulates the processing of p100 NF-κB2 to p52 via an IKKγ/NEMO-independent signaling pathway. Oncogene 2003; 22: 7557-7569 (commentary publication accompanies this paper).
Eliopoulos AG, Wang C-C, Dumitru CD, Tsichlis PN: Tpl2 transduces CD40 and TNF receptor signals that activate ERK and regulate immunoglobulin production. EMBO J 2003; 22: 3855-3864.
Hewison M, Freeman L, Hughes SV, Evans KN, Bland R, Eliopoulos AG, Kilby M, Moss PAH, Chakraverty R: Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. J Immunol 2003; 170: 5382-5390.
Eliopoulos AG, Waites ER, Blake SM, Davies C, Murray P, Young LS: TRAF1 is a critical regulator of JNK signaling by the TRAF-binding domain of the Epstein-Barr virus-encoded latent infection membrane protein 1 but not CD40. J Virology 2003; 77: 1316-1328.
Papadaki HA, Eliopoulos AG, Kosteas T, Gemetzi C, Damianaki A, Koutala H, Bux J, Eliopoulos GD: Impaired granulocytopoiesis in patients with chronic idiopathic neutropenia is associated with increased apoptosis of bone marrow myeloid progenitor cells. Blood 2003; 101: 2591-2600.
Knox PG, Milner AE, Green NK, Eliopoulos AG, Young LS: Inhibition of metalloproteinase cleavage enhances the cytotoxicity of Fas ligand. J Immunol 2003; 170: 677-685.
Dawson CW, Tramountanis G, Eliopoulos AG, Young LS: Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. J Biol Chem 2003; 278: 3694-3704.


2002

Eliopoulos AG, Dumitru CD, Wang CC, Cho J, Tsichlis PN: Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. EMBO J. 2002; 21: 4831-4840.
Gallagher NJ, Eliopoulos AG, Aganthagelo A, Oates J, Crocker J, Young LS: CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion. Mol Pathol 2002; 55: 110-20.
Challa A, Eliopoulos AG, Holder MJ, Burguete AS, Pound JD, Chamba A, Grafton G, Armitage RJ, Gregory CD, Martinez-Valdez H, Young L, Gordon J: Population depletion activates autonomous CD154-dependent survival in biopsy like Burkitt lymphoma cells. Blood 2002; 99: 3411-3418.
Milner AE, Palmer DH, Hodgkin EA, Eliopoulos AG, Knox PG, Poole CJ, Kerr DJ, Young LS: Induction of apoptosis by chemotherapeutic drugs: the role of FADD in activation of caspase-8 and synergy with death receptor ligands in ovarian carcinoma cells. Cell Death Differ 2002; 9: 287-300.
Eliopoulos AG, Davies C, Blake SS, Murray P, Najafipour S, Tsichlis PN, Young LS: The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus-encoded latent infection membrane protein 1-induced NF-kappaB signaling down-stream of TRAF2. J Virology 2002; 76: 4567-4579.


2001

Afford SC, Ahmed-Choudhury J, Randhawa S, Russell C, Youster J, Crosby HA, Eliopoulos AG, Hubscher SG, Young LS, Adams DH: CD40 activation-induced, Fas-dependent apoptosis and NF-kappaB/AP-1 signaling in human intrahepatic bi-liary epithelial cells. FASEB J 2001; 15: 2345-2354.
Blake SM, Eliopoulos AG, Dawson CW, Young LS: The transmembrane domains of the EBV-encoded latent membrane protein 1 (LMP1) variant CAO regulate enhanced signalling activity. Virology 2001; 282: 278-287.
Eliopoulos AG, Young LS: LMP1 structure and signal transduction. Semin Cancer Biol 2001; 11: 435-444.


2000

Young LS, Dawson CW, Eliopoulos AG: The expression and function of Epstein-Barr virus encoded latent genes. Mol Pathol 2000; 53: 238-247.
Eliopoulos AG, Davies C, Knox PG, Gallagher NJ, Afford SC, Adams DH, Young LS: CD40 induces apoptosis in carcinoma cells through activation of cy-totoxic ligands of the tumor necrosis factor superfamily. Mol Cell Biol 2000; 20: 5503-5515.
Dawson CW, Eliopoulos AG, Blake SM, Barker R, Young LS: Identification of functional differences between prototype Epstein-Barr virus-encoded LMP1 and a nasopharyngeal carcinoma-derived LMP1 in human epithelial cells. Virology 2000; 272: 204-217.
 
Eliopoulos' laboratory, cancer research, signaling, CD40, gene therapy, molecular & cellular biology, FP6, Virtual Medical Lab, Faculty of Medicine - University of Crete









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Published on: 2006-04-06 (8118 reads)

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Designed by: George Savakis for Virtual Medical Lab (Faculty of Medicine - Univercity of Crete)